论文

•  Cui, Y., Li, X., Zeljic, K., Shan, S., Qiu, Z.*, Wang, Z.* (2019) Effect of PEGylated magnetic PLGA-PEI nanoparticles on primary hippocampal neurons: reduced nano-neurotoxicity and enhanced transfection efficiency with magnetofection. ACS Applied Materials & Interfaces in press:
•  Zhang, L., Xue, Z., Liu, Q., Liu, Y., Xi, S., Cheng, Y., Li, J., Yan, J., Shen, Y., Xiao, C., Xie, Z.*, Qiu, Z.*, Jiang, H.* (2019) Disrupted folate metabolism with anesthesia leads to myelination deficits mediated by epigenetic regulation of ERMN. EBioMedicine 43: 473-486
•  Tong, D., Chen, R., Lu, Y., Li, W., Zhang, Y., Lin, J., He, L., Dang, T., Shan, S., Xu, X., Zhang, Y., Zhang, C., Du, Y., Zhou, W., Wang, X.*, Qiu, Z.* (2019) The critical role of ASD-related gene CNTNAP3 in regulating synaptic development and social behavior in mice. Neurobiol Dis. 130: 104486
•  Cheng, C., Yang, K., Wu, X., Zhang, Y., Shan, S., Gitler, A., Ghosh, A., Qiu, Z.* (2019) Loss of CREST leads to neuroinflammatory responses and ALS-like motor defects in mice. Transl Neurodegener. 8: 13
•  Cheng, T.*, Li, S., Yuan, B., Wang, X., Zhou, W., Qiu, Z.* (2019) Expanding C–T base editing toolkit with diversified cytidine deaminases. Nat Commun. 10: 3612
•  Cai, Y., Cheng, T., Yao, Y., Li, X., Ma, Y., Bao, J., Li, .L, Zhao, H., Zhang, M.*, Qiu, Z.*, Xue, T.*. (2019) In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Sci. Adv. 5: eaav3335
•  Liu, X., Liu, L., Ji, Y., Li, C., Wei, T., Yang, X., Zhang, Y., Cai, X., Gao, Y., Xu, W., Rao, S., Jin, D., Lou, W.*, Qiu, Z.*, Wang, X.* (2019) Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer. EBioMedicine. 41: 345-356
•  Cheng, T., Qiu, Z.* (2018) Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion. Protein Cell 9: 820-825
•  Qiu, Z.* (2018) Deciphering MECP2 - associated disorders: disrupted circuits and the hope for repair. Curr. Opin. Neurobiol. 48: 30-36
•  Li, X., Yu, B., Sun, Q., Zhang, Y., Ren, M., Zhang, X., Li, A., Yuan, J., Madisen, L., Luo, Q., Zeng, H., Gong, H.*, Qiu, Z.* (2018) Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons. Proc. Natl. Acad. Sci. USA. 115: 415-420
•  Chen, Z., Li, X., Zhou, J., Yuan, B., Yu, B., Tong, D., Cheng, C., Shao, Y., Xia, S., Zhang, R., Lyu, J., Yu, X., Dong, C., Zhou, W., Qiu, Z.* (2017) Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome. Sci. Rep. 7: 41701
•  Yang, K., Yu, B., Cheng, C., Cheng, T., Yuan, B., L,i K., Xiao, J., Qiu, Z.*, Zhou, Y.* (2017) Mir505-3p regulates axonal development via inhibiting the autophagy pathway by targeting Atg12. Autophagy. 13: 1679-1696
•  Wen, Z., Cheng, T., Yin, D., Sun, S., Wang, Z., Yu, S., Zhang, Y.*, Qiu, Z.*, Du, Y.* (2017) Identification of the Genetic Cause for Childhood Disintegrative Disorder by Whole-Exome Sequencing. Neurosci. Bull. 33: 251-254
•  Wen, Z., Cheng, T., Li, G., Sun, S., Yu, S., Zhang, Y.*, Du, Y.*, Qiu, Z.* (2017) Identification of Autism-Related MECP2 Mutations by Whole Exome Sequencing and Functional Validation. M. Autism. 8: 43
•  Ma, S., Sun, R., Jiang, B., Gao, J., Deng, W., Liu, P., He, R., Cui, J., Ji, M., Yi, W., Yang, P., Wu, X., Xiong, Y., Qiu, Z.*, Ye, D.*, Guan, K.*. (2017) L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration. Mol. Cell. Biol. 37: 00492-16
•  Dang, T., Duan, W.,Yu, B., Tong, D.,Cheng, C., Zhang, Y., Wu, W., Ye, K., Zhang, W., Wu, M., Wu, B., An, Y., Qiu, Z.*,Wu, B.* (2018) Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development. Mol. Psy. 23: 747-758
•  Cheng, T.*, Chen, J., Wan, H., Tang, B., Tian, W., Liao, L.*, Qiu, Z.* (2017) Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain. Sci. Rep. 7: 42790
•  Chen, Z., Li, X., Zhou, J., Yuan, B., Yu, B., Tong, D., Cheng, C., Shao, Y., Xia, S., Zhang, R., Lyu, J., Yu, X., Dong, C., Zhou, W., Qiu, Z.* (2017) Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome. Sci. Rep. 7: 41701
•  Tian, Y., Yang, C., Shang, S., Cai, Y., Deng, X., Zhang, J., Shao, F., Zhu, D., Liu, Y., Chen, G., Liang, J.*, Sun, Q.*, Qiu, Z.*, Zhang, C.* (2017) Loss of FMRP impaired hippocampal long-term plasticity and spatial learning in rats. Front. Mol. Neurosci. 10: 269
•  Yuan, B., Cheng, T., Yang, K., Zhang, X., Qiu, Z.* (2017) Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors. J Genet Genomics. 20: 63-66
•  Zhang, D., Yu, B., Liu, J., Jiang, W., Xie, T., Zhang, R., Tong, D., Qiu, Z., Yao, H. (2017) Altered visual cortical processing in a mouse model of MECP2 duplication syndrome. Sci. Rep. 7: 6468
•  Wang, M., Li, H., Takumi, T., Qiu, Z., Xu, X., Yu, X., Bian, W. (2017) Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism. Neurosci Bull. 33: 143-152
•  Liu, Z., Li, X., Zhang, J., Cai, Y., Cheng, T., Cheng, C., Wang, Y., Zhang, C., Nie, Y., Chen, Z., Bian, W., Zhang, L., Xiao, J., Lu, B., Zhang, Y., Zhang, X., Sang, X., Wu, J., Xu, X., Xiong, Z., Zhang, F., Yu, X., Gong, N., Zhou, W., Sun, Q.* & Qiu, Z.* (2016) Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature 530: 98-102
•  Li, H., Zhao, P., Xu, Q., Shan, S., Hu, C., Qiu, Z.*, Xu, X.* (2016) The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1. Sci. Rep. 6: 29878
•  Yao, X., Wang, M., He, X., He, F., Zhang, S., Lu, W., Qiu, Z., Yu, Y. (2016) Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex. Nat Commun. 7: 12229
•  Liu, Z., Nie, Y., Zhang, C., Cai, Y., Wang, Y., Lu, H., Li, Y., Cheng, C., Qiu, Z., Sun, Q.* (2016) Generation of macaques with sperm derived from juvenile monkey testicular xenografts. Cell Res. 26: 139-142
•  Lyu, J., Yuan, B., Cheng, T., Qiu, Z., Zhou, W. (2016) Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs. Sci. Rep. 6: 20392
•  Chen, L., Yin, D., Wang, T., Guo, W., Dong, H., Xu, Q., Luo, Y., Cherasse, Y., Lazarus, M., Qiu, Z., Lu, J., Qu, W., Huang, Z. (2016) Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather than Inducing Behavioral Wakefulness in Mice. Neuropsychopharmacology. 41: 2133-2146
•  Jennings, C., Landman, R., Zhou, Y., Sharma, J., Hyman, J., Movshon, J., Qiu, Z., Roberts, A., Roe, A., Wang, X., Zhou, H., Wang, L., Zhang, F., Desimone, R., Feng, G. (2016) Opportunities and challenges in modeling human brain disorders in transgenic primates. Nat. Neurosci. 19: 1123-1130
•  Zhang, R., Huang, M., Cao, Z., Qi, J., Qiu, Z.*, Chiang, L.* (2015) MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway. Mol Pain. 11: 19
•  Fu, Y, Huang, C., Xu, X., Gu, H., Ye, Y., Jiang, C., Qiu, Z., Xie, X. (2015) Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Res. 25: 1013-1024
•  Bian, W., Miao, W., He, S., Qiu, Z., Yu, X. (2015) Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes. Cell 162: 808-822
•  Jiang, W., Hua, R., Wei, M., Li, C., Qiu, Z., Yang, X., Zhang, C. (2015) An optimized method for high-titer lentivirus preparations without ultracentrifugation. Sci. Rep. 5: 13875
•  Lyu, J., Yu, X., He, L., Cheng, T., Zhou, J., Cheng, C., Chen, Z., Cheng, G., Qiu, Z., Zhou, W. (2015) The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation. Mol Brain. 8: 26
•  Zhou, J., Cheng, C., Qiu, Z., Zhou, W., Cheng, G. (2015) Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis. Neurosci Bull. 31: 763-768
•  Zhang, Y., Chen, M., Qiu, Z., Hu, K., McGee, W., Chen, X., Liu, J., Zhu, L., Wu, J. (2015) MiR-130a regulates neurite outgrowth and dendritic spine density by targeting MeCP2. Protein Cell. 7: 489-500
•  Hou, B., Zhang, D., Zhao, S., Wei, M., Yang, Z., Wang, S., Wang, J., Zhang, X., Liu, B., Fan, L., Li, Y., Qiu, Z., Zhang, C., Jiang, T. (2015) Scalable and DiI-compatible optical clearance of the mammalian brain. Front Neuroanat. 9: 19
•  Chen, L., Ma, S., Zhang, P., Fan, Z., Xiong, M., Cheng, G., Yang, Y., Qiu, Z., Zhou, W., Li, J. (2015) Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury. PLoS One. 10: e0115997
•  Ma, S., Chen, L., Lin, Y., Yan, H., Lv, J., Xiong, M., Li, J., Cheng, G., Yang, Y., Qiu, Z., Zhou, W. (2015) Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury. PLoS One. 10: e0123585
•  Xin, Y., Yuan, B., Yu, B., Wang, Y., Wu, J., Zhou, W.*, Qiu, Z.* (2015) Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress. Sci. Rep. 5: 7645
•  Liu, Z., Zhou, X., Zhu, Y., Chen, Z., Yu, B., Wang, Y., Zhang, C., Nie, Y., Sang, X., Cai, Y., Zhang, Y., Zhang, C., Zhou, W., Sun, Q.*, and Qiu, Z.* (2014) Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci. Bull. 30: 381-386
•  Zhang, Y., Mao, R., Chen, Z., Tian, M., Tong, D., Gao, Z., Huang, M., Li, X., Xu, X., Zhou, W., Li, C., Wang, J., Xu, L.*, Qiu, Z.* (2014) Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders. Mol. Brain 7: 11
•  He, L., Liu, N., Cheng, T., Chen, X., Li, Y., Shu, Y., Qiu, Z., Zhang, X. (2014) Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity. Nat Commun. 5: 5036
•  Yang, L., Shen, C., Mei, M., Zhan, G., Zhao, Y., Wang, H., Huang, G., Qiu, Z., Lu, W., Zhou, W. (2014) De novo GLI3 mutation in esophageal atresia: reproducing the phenotypic spectrum of Gli3 defects in murine models. Biochim Biophys Acta. 1842: 1755-1761
•  Cheng, T., Wang, Z., Liao, Q., Zhu, Y., Zhou, W., Xu, W., Qiu, Z.* (2014) MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Dev. Dev. Cell 28: 547-560
•  Lv, J., Xin, Y., Zhou, W., Qiu, Z.* (2013) The epigenetic switches for neural development and psychiatric disorders. Genet. Genomics 40: 339-346
•  Cheng, J., Huang, M., Zhu, Y., Xin, Y., Zhao, Y., Huang, J., Yu, J., Zhou, W.*, and Qiu, Z.* (2013) SUMOylation of MeCP2 is essential for transcriptional rep ression and hippocampal synapse development. J. Neurochem. 128: 798-806
•  Xu, X., Xu, Q., Zhang, Y., Zhang, X., Cheng, T., Wu, B., Ding, Y., Lu, P., Zheng, J., Zhang, M., Qiu, Z., Yu, X. (2012) A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections. BMC Med Genet. 13: 75
•  Gong, X., Jiang, Y., Zhang, X., An, Y., Zhang, J., Wu, Y., Wang, J., Sun, Y., Liu, Y., Gao, X., Shen, Y., Wu, X., Qiu, Z., Jin, L., Wu, B., Wang, H. (2012) High Proportion of 22q13 Deletions and SHANK3 Mutations in Chinese Patients with Intellectual Disability. PLoS One. 7: e34739
•  Wilke, S., Hall, B., Antonios, J., Denardo, L., Otto, S., Yuan, B., Chen, F., Robbins, E., Tiglio, K., Williams, M., Qiu, Z., Biederer, T., Ghosh, A. (2012) NeuroD2 regulates the development of hippocampal mossy fiber synapses. Neural Dev. 27: 7--9
•  Liu, X., Somel, M., Tang, L., Yan, Z., Jiang, X., Guo,S., Yuan,Y., Oleksiak, A., Zhang, Y., Li, N., Hu, Y., Chen, W., Qiu, Z.*, P??bo, S.*, Khaitovich, P.* (2012) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. 22: 611-622
•  Qiu, Z., Sylwestrak, E., Lieberman, D., Zhang, Y., Liu, X., Ghosh A.* (2012) The Rett syndrome protein MeCP2 regulates synaptic scaling. J. Neurosci. 32: 989-994
•  Qiu, Z.*, and Cheng, J. (2010) The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond. Neurosignals 18: 72-81
•  Qiu, Z.* (2009) Histone modifier, the gatekeeper of good memory. Cell Res. 8: 920-921
•  Qiu, Z., and Ghosh, A.* (2008) A brief history of neuronal gene regulation: regulatory mechanisms and cellular consequences. Neuron 60: 449-455
•  Qiu, Z., and Ghosh, A.* (2008) A Calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 60: 775-787
•  Yuan, S., Qiu, Z., Ghosh, A.* (2008) Tox3: a CREB- and CBP-interacted protein that regulates calcium-dependent transcription in neurons. Proc. Natl. Acad. Sci. USA. 106: 2909-2914
•  Wu, J., Lessard, J., Olave, I., Qiu, Z., Ghosh, A., Graef, I., Crabtree, G. R. (2007) Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron 56: 94-108
•  Kashani, A., Qiu, Z., Jurata, L., Lee, S. K., Pfaff, S., Goebbels, S., Nave, K. A., Ghosh, A.* (2006) Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J. Neurosci. 26: 8398-8408
•  Qiu, Z., Guo, X. M. Liao, K.* (2001) Analysis of the Relationship between Globally Regulated Genes and Their Chromosomal Genetic Map Loci during Adipogenesis. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 33: 137-141
•  Qiu, Z., Wei, Y., Chen, N., Jiang, M., Wu, J.*, Liao, K.* (2001) DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J. Biol. Chem. 276: 11988-11995
•  Jin, S., Zhai, B., Qiu, Z., Wu, J., Lane, M. D., Liao, K.* (2000) c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as an early signal mediator in the adipocyte differentiation process. J. Biol. Chem. 275: 34344-34352