当前位置: 首页>研究组>徐敏>新闻

Long-range and local circuits for top-down modulation of visual cortex processing

发布时间:2019-06-02

Zhang S, Xu M, et al.  Science, 2014

Top-down modulation of sensory processing allows the animal to select inputs most relevant to current tasks.We found that the cingulate (Cg) region of the mouse frontal cortex powerfully influences sensory processing in the primary visual cortex (V1) through long-range projections that activate local GABAergic circuits. Optogenetic activation of Cg neurons enhanced V1 neuron responses and improved visual discrimination. Focal activation of Cg axons in V1 caused a response increase at the activation site but a decrease at nearby locations (center-surround modulation). Whereas SOM+  GABAergic interneurons contributed preferentially to surround suppression, VIP+ interneurons were crucial for center facilitation. Long-range corticocortical projections thus act through local microcircuits to exert spatially specific top-down modulation of sensory processing.


附件下载: