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Age differences in the fronto-striato-parietal network underlying serial ordering

发布时间:2020-01-09

新闻内容

      Ordering-related regional activation

  A shows the ordering-related regional activation common to older and young participants. The whole-brain two-sample t-test (voxel-level p<0.001, cluster-level p<0.05 family-wise-error-corrected) revealed greater activations for REO+ than REOtrials in the dorsomedial prefrontal cortex (BA8/6: peak in MNI coordinates [-3, 9,54], t=10.48, 1218 voxels), dorsolateral prefrontal cortex (BA9/46: left [-48, 12, 30],t=8.29, 217 voxels; right [45, 33, 24], t=6.66, 83 voxels), ventrolateral prefrontal cortex (BA44/45: left [-54, 9, 12], t=7.03, 139 voxels; right [57, 9, 18], t=6.10, 60 voxels), posterior parietal cortex (BA7/40: left [-36, -45, 36], t=9.38, 780 voxels; right [45, -45, 45], t=9.14, 684 voxels), thalamus (left [-12, -3, 12], t=9.83, 96 voxels; right [12, -3, 12], t=6.59, 45 voxels), globus pallidus (left [-15, -3, 9], t=7.15, 32 voxels; right [15, 0, 9], t=6.21, 23 voxels), subthalamic nucleus ([-12, -15, -9], t=4.43, 5voxels), substantia nigra ([-9, -18, -12], t=5.24, 6 voxels), and cerebellum (VI/Crus I:[-27, -63, -36], t=9.51, 655 voxels; VIIIa/VIIb: [3, -72, -33], t=6.15, 19 voxels).

       Ordering-related regional deactivation

  We also observed the ordering-related regional deactivation across age groups(B). The whole-brain two-sample t-test (voxel-level p<0.001, cluster-level p<0.05 family-wise-error-corrected) revealed greater deactivations for REO+ than REO- trials in the default mode network, including the ventromedial prefrontal cortex ([6, 51, 12], t=7.19, 1245 voxels), posterior cingulate cortex ([-6, -54, 12], t=6.65, 509 voxels), and Rolandic operculum (left [-42, -18, 18], t=4.93, 33 voxels; right [48, -27,21], t=5.25, 61 voxels).

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