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Differentiating spine fate: a novel role of cadherin/catenin complex during spine pruning (2015-8-7)
In a recent study published online in Cell, Dr. YU Xiang’s research group demonstrated a novel mechanism through which the pruning and maturation of dendritic spines in the developing brain are coordinated by the cadherin/catenin cell adhesion complex.
2015 ION Mini-Symposium on Systems Neuroscience (2015-7-7)
The 2015 ION Mini-Symposium on Systems Neuroscience was held at the Institute of Neuroscience on July 4th, 2015. Profs. Jose Carmena (University of California, Berkeley, USA), Vikaas Sohal (University of California, San Francisco, USA), Nirao Shah University of California, San Francisco, USA ), Botond Roska (University of Basel, Switzerland) presented their recent findings. Prof. Muming Poo hosted this symposium. More than 160 researchers from ION attended this symposium.
Unraveling a novel signaling cascade determining dopamine transporter activity and its association with cocaine addiction (2015-7-7)
In a recent study, Dr. ZHOU Jiawei’s lab found that a Rho family GEF protein Vav2 is required for glial cell line-derived neurotrophic factor (GDNF) and its cognate receptor Ret-modulated DAT cell surface expression and transporter activity.
Reprogramming Study Reveals Single Transcription Factor Ascl1 Converts Astrocytes into Neurons in the Intact Brain (2015-6-26)
A recent study, published in the June 24th issue of the Journal of Neuroscience, demonstrated that expression of a single transcription factor efficiently induced astrocyte-to-neurons conversion in the intact brain. This work provides a novel approach to obtain functional neurons in the intact brain and a potential therapeutic solution for neural regeneration.
2015 ION Mini-Symposium on Glial Cell Development and Function (2015-6-24)
The 2015 ION Mini-Symposium on Glial Cell Development and Function was held at the Institute of Neuroscience on June 19th, 2015. Profs. Benjamin Deneen (Baylor College of Medicine, USA), Changjoon Justin Lee (Institute of Science & Technology, Korea), Masamitsu Iino (University of Tokyo, Japan), Marco Prinz (University of Freiburg, Germany) presented their recent findings.
BDNF acts as an autocrine factor in regulating dendrite development of newborn neurons in adult hippocampus (2015-6-13)
In a recent study, graduate student WANG Liang under the supervision of Dr. POO Mu-ming, examined the function of brain-derived neurotrophic factor (BDNF), which is expressed in adult-born GCs, in regulating their dendrite morphogenesis.
Traction Force Microscopy Revealed Dynamics of Contraction Force Generation in Migrating Neurons (2015-6-9)
A recent study published on the Journal of Cell Biology demonstrated that the neuron migration is controlled by three highly dynamic contraction centers (CCs) which are regulated by guidance cues. This work was performed mainly by graduate student JIANG Jian in the laboratory of POO Mu-ming.
A New Method to Identify the Structured Biomarkers of Macroscale Brain Connectomes (2015-6-2)
In a recent study, Dr. WANG Zheng’s lab proposed a novel method to unveil the intrinsic features of functional brain connectivity matrices of discriminative power for group comparison. Morespecifically, by encouraging co-selection of edges connected to the same node in the connectivity matrix, the discriminative edges are preserved to maximumextent.
Dr. Jiulin Du gave invited talks at HHMI Janelia Farm, University of Michigan, Yale University and Harvard University (2015-5-26)
During May 14 - 26, Dr. Jiulin Du was invited to attend an international symposium on “Combining Information from Multiple Modalities Across the Animal Kingdom” held by HHMI at Janelia Farm, and was invited to visit University of Michigan, Yale University and Harvard University, and gave seminars about neuromodulation-mediated cross-modal modulation and sensorimotor transformation control”.
Dr. Jiulin Du gave an invited talk at the HHMI Symposium on Zebrafish System Neuroscience held at Janelia Farm, US (2015-4-27)
Dr. Jiulin Du was invited to attend the Third Zebrafish Symposium on System Neuroscience held by HHMI at Janelia Farm during April 22 – 25, and gave a talk entitled “Visual cue-specific dopaminergic control of visuomotor transformation and behavior selection”.
An important role of Parvalbumin-expressing interneurons in controlling the response reliability in visual cortex (2015-4-16)
A recent study from Dr. YAO Haishan's lab at the Institute of Neuroscience, Shanghai Institutes for Biological Sciences, demonstrated that Parvalbumin (PV)-expressing interneurons play an important role in controlling the response reliability of excitatory neurons in the primary visual cortex (V1).
The Brain Circuits Responsible for Sustained, Efficacious Antidepressant Effects by Ketamine (2015-3-26)
In a recent study, graduate student LV Qian and postdoc YANG Liqin under the supervision of Dr. WANG Zheng and Dr. HU Hailan, conducted a randomized, placebo-controlled functional connectome study on anesthetized monkeys 18 hours after ketamine and saline administration.
Dr. Jiulin Du gave an invited talk at an International Microglia Symposium held at Okinawa, Japan (2015-3-2)
Dr. Jiulin Du was invited to attend the International Symposium “Microglia: key to understand neural development and pathology” held by Okinawa Institute of Science and Technology during Feb. 27 to March 02, and gave a talk entitled “Interaction between microglia and neurons”.
Researchers reveal auxiliary subunits of Kv4 channels regulate animal behaviors (2015-2-11)
A study from Dr. CAI Shiqing's lab at the Institute of Neuroscience, identified three C. elegans KChIP-like (ceKChIP) proteins, NCS-4, NCS-5, and NCS-7. This research was published in the Journal of Neuroscience on February 4, 2015. This work was mainly carried out by graduate student CHEN Xin and research assistant RUAN Meiyu.
Researchers reveal the function of Rcan1 in cortical development and the pathogenesis of periventricular heterotopia (2015-1-19)
In a recent study, graduate student LI Yang and colleagues under the supervision of Dr. XIONG Zhi-Qi, reported that Regulators of calcineurin 1 (Rcan1), a Down Syndrome-related gene, plays an important role in radial migration of rat cortical neurons.
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