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Baibing Zhang from Jiulin Du’s lab won a poster prize in CSHAsia Conference (2016-5-24)
The Cold Spring Harbor Asia conference – “Development, Function and Disease of Neural Circuits” was held in Suzhou from May 16th to 20th, 2016. Baibing Zhang from Jiulin Du’s lab in the Institute of Neuroscience won the first prize in poster presentation at this conference. Her study is entitled “Habenula mediates light-preference behavior in zebrafish via receiving direct visual inputs”.
Causal Link between Vertical ZIKV Infection and Malformation of Fetal Brain Established (2016-5-13)
Recently, a collaborative work between research teams of Dr. LUO Zhenge at Institute of Neuroscience and Dr. QIN Chengfeng has established the causal link between maternal ZIKV infection and malformation of the fetal brain in a mouse model. They show that maternally infected ZIKV can cross the mouse placental barrier, infect radial glial cells of the fetal brain .
Distributed Representation of Curvilinear Self-Motion in Macaque Parietal Cortex (2016-4-22)
In a recent study published online on April 21st in Cell reports, Dr. GU's lab at the Institute of Neuroscience, unveiled that single neurons in three cortical areas: the dorsal portion of the medial superior temporal area (MSTd), ventral intraparietal area (VIP), and visual posterior sylvian fissure (VPS), can integrate the translation and rotation signals with linear weights to represent curvilinear self-motion perception.
Dr. Jiulin Du gave an invited talk at the International Neuroscience Conference “Linking cellular properties to neuronal network dynamics” in France (2016-4-20)
During April 16 – 18, Dr. Jiulin Du was invited to attend an international neuroscience symposium on “Linking cellular properties to neuronal network dynamics” held in Marseille, France, and gave a talk entitled “Mapping neural circuits with a whole-brain scale by using larval zebrafish”.
Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy (2016-4-12)
In a recent study, researchers at the Institute of Neuroscience, reported that sonic hedgehog (Shh) inhibits glutamate transporter activities in neurons to rapidly enhance extracellular glutamate levels and affect the development of epilepsy.
Workshop on "The Future of Brain & Cognition" was held at Institute of Neuroscience (2016-4-6)
From March 31st to April 1st, the Workshop on "The Future of Brain & Cognition" was held at the Institute of Neuroscience (ION). This workshop was organized by the Chinese Academy of Sciences (CAS) and the Netherlands Organisation for Scientific Research (NWO).
Institute of Neuroscience Mini-Course on “Scientific Communication, Integrity and Innovation” (2016-3-18)
From February 23 to March 17, the ION Mini-Course on “Scientific Communication, Integrity and Innovation” was held in the SIBS main lecture hall by Prof. Mu-ming Poo (ION). More than 200 researchers attended the classes, mostly students from ION and including some were from other SIBS institutes.
Representation of Pinna Illusory and Physical Rotations in Human MST (2016-3-17)
The laboratories of Drs GU Yong, WANG Zheng, and WANG Wei, have collaborated closely to solve the above ‘where’ question, i.e. which visual brain mediates the Pinna illusion, a prerequisite for gaining further insights intothe ‘how’ question, i.e. how neurons in the visual brain integrate local visual cues to form a global representation of a compelling movement illusion.
Identification of V2 Neuronal Receptive Field in Awake Monkey (2016-2-23)
A recent study published online on February16th in the Proceedings of the National Academy of Sciences demonstrated the fine spatial structure of neuronal receptive field (RF) in awake monkey secondary visual cortex (V2),using electrophysiological recording and computational modeling.
Transgenic Monkeys Overexpressing Human Mecp2 Gene Exhibit Autism-Like Behaviors and Germline Transmission (2016-1-26)
A recent study published in Nature demonstrated that transgenic monkeys overexpressing human autism-related gene MECP2 exhibited autism-like behaviors and germ-line transmission. This work was performed by researchers in Dr. QIU Zilong’s Lab and Dr. SUN Qiang’s team.
Behavior Selection Controlled by a Dopaminergic-Inhibitory Neural Circuit (2016-1-22)
In a article published online in NEURON on January 22, entitled "Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection", Dr. DU Jiulin's lab identified a novel circuit mechanism through which behavior selection is controlled at the stage of visuomotor transformation by a visually responsive dopaminergic-inhibitory neural module.This work was carried out by YAO Yuanyuan, LI Xiaoquan, ZHANG Baibing and collaborators under the supervision of Dr. DU Jiulin. This work was carried out by YAO Yuanyuan, LI Xiaoquan, ZHANG Baibing and collaborators under the supervision of Dr. DU Jiulin.
2015 ION Annual Meeting (2016-1-4)
The 2015 ION Annual Meeting was held at the SIBS Lecture Hall from December 28th to 30th, 2015. Fifty-five ION researchers and new faculty members presented their recent works. Drs. Qiang Sun and Neng Gong reported their interesting findings on primate research. Dr. Qian Hu introduced the equipments and services of the Optical Imaging Facility. Prof. Poo gave a talk entitled “Brain science research in China”. The prizes for the best five presentations were awarded to Han Hou, Bai-Bing Zhang, Han-Fei Deng, Xin Jiang and Dan-Qian Liu.
Identifying Somatosensory Neuron Types by Single-Cell RNA-Sequencing and Functional Heterogeneity (2015-12-29)
Somatosensory neuron types were identified by high-coverage single-cell RNA-sequencing and functional heterogeneity, as reported on Dec. 22th in Cell Research. High-coverage single-cell RNA-sequencing was performed to identify neuron types by size-based hierarchical clustering. Physiological functions were determined by the responses of somatosensory neuron to peripheral stimuli recorded by in vivo patch clamp.
In vivo monitoring of dopamine release in a transparent brain (2015-11-20)
In a recent study, Dr. DU Jiulin’s lab found that Dopamine release can be evoked by a hedonic olfactory stimulus, monitored in real time, and traced to its circuit origin in the transparent brain of zebrafish larvae. This work demonstrated for the first time that sensory-evoked dopamine release can be successfully monitored in the brain of an awake small organism.
TRPC6 Specifically Inhibits Aβ Production (2015-11-20)
In a recent study, researchers at the Institute of Neuroscience, reported that Transient receptor potential canonical (TRPC) 6 blocked the interaction between APP and γ-secretase to specifically suppress Aβ production. TRPC6 specifically interacts with APP (C99), but not with Notch, and prevents C99 interaction with presenilin 1 (PS1), leading to inhibition of γ-secretase cleavage of APP and Aβ production. A fusion peptide derived from TRPC6 also reduced Aβ levels without affecting Notch cleavage.
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