ION Structure
ION Quarterly Report
Autophagy Induction Promotes Axon Regeneration after Spinal Cord Injury (2016-9-18)
Researchers from Dr. LUO Zhenge's lab demonstrate a role of autophagy in regulating microtubule dynamics and axon regeneration. They found that autophagy induction promoted neurite outgrowth, attenuated the inhibitory effects of nonpermissive substrate myelin, and decreased the formation of retraction bulbs following axonal injury in cultured cortical neurons.
Lateral Amygdala to Auditory Cortex Projections Play a Key Role in Fear Conditioning and Exhibit Selective Synaptic Remodeling after Fear Learning (2016-9-6)
A recent paper published in Nature Neuroscience uncovered a pathway from the lateral amygdala to the auditory cortexin mice, which plays a key role in auditory fear memory, and undergoes pathway-specific synaptic plasticity after fear conditioning.
Expression of a hominoid-specific gene induces cortical folding in mice (2016-8-10)
On Aug 9th, eLife published a paper entitled " The hominoid-specific gene TBC1D3 promotes generation of basal neural progenitors and induces cortical folding in mice" from Dr. LUO Zhenge's group. This study was mainly conducted by graduate students JU Xiangchun and HOU Qiongqiong under the supervision of Dr. LUO Zhenge。
Kai Li from Shiqing Cai's lab won the best poster prize in Gordon Research Conference - Ion Channel (2016-8-1)
The Gordon Research Conferences–“Ion Channel” was held in Mount Holyoke College in Boston (USA) from July 10th to 16th 2016.Kai Li from Shiqing Cai’s lab in the Institute of Neuroscience won the best prize in poster presentation at this conference. His work is entitled “Tetrameric assembly of K+ channels requires ER-located chaperone proteins”.
Dr. DU Jiulin Was Invited to Write a Preview Entitled “A Death Trap for Microglia” in Developmental Cell (2016-7-26)
On July 26, 2016, Prof. DU Jiulin’s research group published an invited commentary paper entitled “A Death Trap for Microglia” in Developmental Cell to recommend two research articles published in the same issue of Developmental Cell and the latest issue of Cell Reports, respectively.
Researchers Reveal Periaqueductal Gray Neuronal Activities Underlying Differentaspects of Defensive Behaviors (2016-7-21)
To explore the exact role of PAG in defensive behaviors, Dr. WANG Zuoren’s lab first examined the behavioral effects of optogenetic activation of dorsal PAG in mice. They found that optogenetic activation of neurons in the dorsal PAG was sufficient to induce a series of defensive responses (including running, freezing, and avoidance).
TMC gene regulates Drosophila larval locomotion (2016-7-11)
In a recent paper entitled “Transmembrane channel-like (tmc) gene regulates Drosophila larval locomotion” publishedin PNAS USA on June 28th, the research teams of Dr. WANG Zuo-Ren at the Institute of Neuroscience and Dr. JAN Yuh-Nung at UCSF reported that Drosophila TMC regulates fly larval locomotion. Locomotion requires peripheral sensory feedback from mechanosensitive proprioceptors. The molecular mechanisms underlying this proprioceptive locomotion control are largely unknown.
Dr. Wei Wang was promoted to Senior Investigator at ION (2016-6-23)
Based on recommendations of the International Academic Review Committee, ION senior investigators have voted anonymously to promote Dr. Wei Wang to ION senior investigator.
Neuroscientist Mu-ming Poo Receives $500,000 Gruber Neuroscience Prize for His Pioneering and Inspiring Work on Synaptic Plasticity (2016-6-8)
June 7, 2016, New Haven, CT Mu-Ming Poo, PhD, a world-renowned researcher whose innovative work has helped unravel some of the most important mysteries in cellular neuroscience, is the recipient of the 2016 Gruber Neuroscience Prize.
The 7th Academic Review of ION PIs and the 8th International Advisory Board Meeting were held in Shanghai (2016-6-2)
From May 30 to June 1, the 7th Academic Review of ION PIs and the 8th International Advisory Board Meeting were held in Shanghai.In the afternoon of June 1st, committee members gave talks in the Shanghai Symposium on Frontiers of Neuroscience organized by ION.
Baibing Zhang from Jiulin Du’s lab won a poster prize in CSHAsia Conference (2016-5-24)
The Cold Spring Harbor Asia conference – “Development, Function and Disease of Neural Circuits” was held in Suzhou from May 16th to 20th, 2016. Baibing Zhang from Jiulin Du’s lab in the Institute of Neuroscience won the first prize in poster presentation at this conference. Her study is entitled “Habenula mediates light-preference behavior in zebrafish via receiving direct visual inputs”.
Causal Link between Vertical ZIKV Infection and Malformation of Fetal Brain Established (2016-5-13)
Recently, a collaborative work between research teams of Dr. LUO Zhenge at Institute of Neuroscience and Dr. QIN Chengfeng has established the causal link between maternal ZIKV infection and malformation of the fetal brain in a mouse model. They show that maternally infected ZIKV can cross the mouse placental barrier, infect radial glial cells of the fetal brain .
Distributed Representation of Curvilinear Self-Motion in Macaque Parietal Cortex (2016-4-22)
In a recent study published online on April 21st in Cell reports, Dr. GU's lab at the Institute of Neuroscience, unveiled that single neurons in three cortical areas: the dorsal portion of the medial superior temporal area (MSTd), ventral intraparietal area (VIP), and visual posterior sylvian fissure (VPS), can integrate the translation and rotation signals with linear weights to represent curvilinear self-motion perception.
Dr. Jiulin Du gave an invited talk at the International Neuroscience Conference “Linking cellular properties to neuronal network dynamics” in France (2016-4-20)
During April 16 – 18, Dr. Jiulin Du was invited to attend an international neuroscience symposium on “Linking cellular properties to neuronal network dynamics” held in Marseille, France, and gave a talk entitled “Mapping neural circuits with a whole-brain scale by using larval zebrafish”.
Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy (2016-4-12)
In a recent study, researchers at the Institute of Neuroscience, reported that sonic hedgehog (Shh) inhibits glutamate transporter activities in neurons to rapidly enhance extracellular glutamate levels and affect the development of epilepsy.
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