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Distributed Representation of Curvilinear Self-Motion in Macaque Parietal Cortex (2016-4-22)
In a recent study published online on April 21st in Cell reports, Dr. GU's lab at the Institute of Neuroscience, unveiled that single neurons in three cortical areas: the dorsal portion of the medial superior temporal area (MSTd), ventral intraparietal area (VIP), and visual posterior sylvian fissure (VPS), can integrate the translation and rotation signals with linear weights to represent curvilinear self-motion perception.
Dr. Jiulin Du gave an invited talk at the International Neuroscience Conference “Linking cellular properties to neuronal network dynamics” in France (2016-4-20)
During April 16 – 18, Dr. Jiulin Du was invited to attend an international neuroscience symposium on “Linking cellular properties to neuronal network dynamics” held in Marseille, France, and gave a talk entitled “Mapping neural circuits with a whole-brain scale by using larval zebrafish”.
Sonic hedgehog is a regulator of extracellular glutamate levels and epilepsy (2016-4-12)
In a recent study, researchers at the Institute of Neuroscience, reported that sonic hedgehog (Shh) inhibits glutamate transporter activities in neurons to rapidly enhance extracellular glutamate levels and affect the development of epilepsy.
Workshop on "The Future of Brain & Cognition" was held at Institute of Neuroscience (2016-4-6)
From March 31st to April 1st, the Workshop on "The Future of Brain & Cognition" was held at the Institute of Neuroscience (ION). This workshop was organized by the Chinese Academy of Sciences (CAS) and the Netherlands Organisation for Scientific Research (NWO).
Institute of Neuroscience Mini-Course on “Scientific Communication, Integrity and Innovation” (2016-3-18)
From February 23 to March 17, the ION Mini-Course on “Scientific Communication, Integrity and Innovation” was held in the SIBS main lecture hall by Prof. Mu-ming Poo (ION). More than 200 researchers attended the classes, mostly students from ION and including some were from other SIBS institutes.
Representation of Pinna Illusory and Physical Rotations in Human MST (2016-3-17)
The laboratories of Drs GU Yong, WANG Zheng, and WANG Wei, have collaborated closely to solve the above ‘where’ question, i.e. which visual brain mediates the Pinna illusion, a prerequisite for gaining further insights intothe ‘how’ question, i.e. how neurons in the visual brain integrate local visual cues to form a global representation of a compelling movement illusion.
Identification of V2 Neuronal Receptive Field in Awake Monkey (2016-2-23)
A recent study published online on February16th in the Proceedings of the National Academy of Sciences demonstrated the fine spatial structure of neuronal receptive field (RF) in awake monkey secondary visual cortex (V2),using electrophysiological recording and computational modeling.
Transgenic Monkeys Overexpressing Human Mecp2 Gene Exhibit Autism-Like Behaviors and Germline Transmission (2016-1-26)
A recent study published in Nature demonstrated that transgenic monkeys overexpressing human autism-related gene MECP2 exhibited autism-like behaviors and germ-line transmission. This work was performed by researchers in Dr. QIU Zilong’s Lab and Dr. SUN Qiang’s team.
Behavior Selection Controlled by a Dopaminergic-Inhibitory Neural Circuit (2016-1-22)
In a article published online in NEURON on January 22, entitled "Visual Cue-Discriminative Dopaminergic Control of Visuomotor Transformation and Behavior Selection", Dr. DU Jiulin's lab identified a novel circuit mechanism through which behavior selection is controlled at the stage of visuomotor transformation by a visually responsive dopaminergic-inhibitory neural module.This work was carried out by YAO Yuanyuan, LI Xiaoquan, ZHANG Baibing and collaborators under the supervision of Dr. DU Jiulin. This work was carried out by YAO Yuanyuan, LI Xiaoquan, ZHANG Baibing and collaborators under the supervision of Dr. DU Jiulin.
2015 ION Annual Meeting (2016-1-4)
The 2015 ION Annual Meeting was held at the SIBS Lecture Hall from December 28th to 30th, 2015. Fifty-five ION researchers and new faculty members presented their recent works. Drs. Qiang Sun and Neng Gong reported their interesting findings on primate research. Dr. Qian Hu introduced the equipments and services of the Optical Imaging Facility. Prof. Poo gave a talk entitled “Brain science research in China”. The prizes for the best five presentations were awarded to Han Hou, Bai-Bing Zhang, Han-Fei Deng, Xin Jiang and Dan-Qian Liu.
Identifying Somatosensory Neuron Types by Single-Cell RNA-Sequencing and Functional Heterogeneity (2015-12-29)
Somatosensory neuron types were identified by high-coverage single-cell RNA-sequencing and functional heterogeneity, as reported on Dec. 22th in Cell Research. High-coverage single-cell RNA-sequencing was performed to identify neuron types by size-based hierarchical clustering. Physiological functions were determined by the responses of somatosensory neuron to peripheral stimuli recorded by in vivo patch clamp.
In vivo monitoring of dopamine release in a transparent brain (2015-11-20)
In a recent study, Dr. DU Jiulin’s lab found that Dopamine release can be evoked by a hedonic olfactory stimulus, monitored in real time, and traced to its circuit origin in the transparent brain of zebrafish larvae. This work demonstrated for the first time that sensory-evoked dopamine release can be successfully monitored in the brain of an awake small organism.
TRPC6 Specifically Inhibits Aβ Production (2015-11-20)
In a recent study, researchers at the Institute of Neuroscience, reported that Transient receptor potential canonical (TRPC) 6 blocked the interaction between APP and γ-secretase to specifically suppress Aβ production. TRPC6 specifically interacts with APP (C99), but not with Notch, and prevents C99 interaction with presenilin 1 (PS1), leading to inhibition of γ-secretase cleavage of APP and Aβ production. A fusion peptide derived from TRPC6 also reduced Aβ levels without affecting Notch cleavage.
Visit by a Delegation from the Brain Science Institute of the Korea Institute of Science and Technology (2015-11-9)
A Delegation from the Brain Science Institute of the Korea Institute of Science and Technology (KIST-BSI) visited ION on November 8, 2015. Members included Profs. Dennis Choi (Director General of KIST-BSI), Changjoon Justin Lee and Dongjin Kim.
Testicular xenografting shorten the reproduction cycle of transgenic monkeys (2015-9-17)
In a recent study, Dr. SUN Qiang’s research group successfully accelerated the sexual maturity of juvenile cynomolgus monkeys by testicular xenografting. Testicular tissues were obtained from one 14-month wild-type (WT) and one 27-month HA-hMeCP2-2a-GFP transgenic(Tg) monkey, and implanted subcutaneously in adult castrated nude mice.
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