ION Structure
ION Quarterly Report
Pre-synaptic Cadherin/Catenin Complexes Drive Post-Synaptic Dendritic Spine Stabilization in vivo (2017-6-22)
A recent study entitled “A critical role of pre-synaptic cadherin/catenin/p140Cap complexes in stabilizing spines and functional synapses in the neocortex” from Dr. YU Xiang’s lab at the Institute of Neuroscience, Chinese Academy of Sciences was published in Neuron on June 21, 2017. The effect of the cadherin/catenin requires p140Cap —— a novel β-catenin interacting partner.
Generating Complete Knockout Mice and Monkey by Optimized CRISPR (2017-6-7)
A recent study published in Cell Research demonstrated that single gene or multiple genes could be nearly 100% deleted in all cells of CRISPR/Cas9-injected mice and monkeys, using a modified “C-CRISPR” approach.
Homology-Mediated End Joining-Based Strategy Showed Robust DNA Targeted Integration Efficiency both in vitro and in vivo (2017-5-20)
A recent study published in Cell Research demonstrated that homology-mediated end joining (HMEJ)-based strategy can induce robust and efficient DNA targeted integration using CRISPR/Cas9. This work was performed by researchers in Dr. YANG Hui’s Lab.
Embryonic Origin of Retinal Stem Cells (2017-5-3)
Using zebrafish and cytobow-based clonal analysis, Dr HE Jie's team identified the cells in the second or the third layer of the CMZ as the RSCs which were slow-cycling as compared to retina progenitors in CMZ. Moreover, the study also identified a novel set of dormant CMZ tip cells, which may serve as a critical cellular component in the niche.
Neurons Regulate Brain Vascular Integrity by Secreting Exosomes (2017-4-24)
A recent study published online in Cell Research reported that neurons transfer miR-132 into brain vascular endothelial cells (ECs) via exosomes to promote brain vascular integrity. This study was performed by Dr. DU Jiulin’s research group in the Institute of Neuroscience and the Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.
Researchers Reveal the Role of Long Noncoding RNAs in Circadian Gene Regulation (2017-4-7)
A recent study by Dr. YAN Jun’s lab at the Institute of Neuroscience, Chinese Academy of Sciences, was published in Nucleic Acids Research on March 8. It uncovered that a class of enhancer-associated circadian long noncoding RNAs (lncRNAs) mark the genomic loci modulating long-range circadian gene regulation.
Functional Circuits Regulating the Activity of Serotonergic Neurons (2017-3-22)
A recent study published in Cell Reports systematically analyzed the circuit mechanism underlying dynamic control of serotonergic neuron in the rodent brain. This work was performed by researchers in Dr. SUN Yangang’s Lab. This work advanced our understanding of the mechanisms regulating the serotonin system, which could have important impact on studying the mechanisms of mental disorder.
Monkeys Spontaneously Show Mirror Self-Recognition after Learning Precise Instrumental Mirror Use (2017-2-14)
A recent study published in PNAS demonstrated that monkeys showed spontaneous mirror self-recognition (MSR) behaviors after learning precise visual-proprioceptive association for mirror images. This work was performed by researchers in Dr. GONG Neng’s team.
Light-preference Behavior Mediated by Asymmetrical Visual Pathway to Left Habenula (2017-2-10)
A recent study published online in Neuron discovered that visual inputs from an asymmetrical pathway in larval zebrafish, comprising of a specific subset of RGCs, EmT and L-dHb mediates light-preference behavior. This work was performed by Dr. DU Jiulin’s research group.
Autism-Associated Dyrk1a Truncations Inhibit Neural Dendritic and Spine Growth and Interfere with Cortical Migration during Development (2017-2-8)
A recent study published in Molecular Psychiatry demonstrated that autism-associated Dyrk1a truncations inhibit neural dendritic and spine growth and interfere with cortical migration during development. This work was performed by Dr. QIU Zilong’s Lab.
New Membrane Signal Paradigm in Regulation of Cortical Neuron Migration (2017-2-6)
Recently a research finding describing the critical role of ADAM10-initiated release of Notch intracellular domain in the radial migration of cortical neurons was published online in Cerebral Cortex. In this work, researchers from Dr. XIONG Zhiqi’s lab.
FGF13 Acts as a Selective Regulator of Heat Nociception (2017-2-3)
A recent study published in Neuron shows that fibroblast growth factor 13 (FGF13) plays a critical role in the regulation of heat nociception. This research work was carried out by Dr. ZHANG Xu’s Lab at the Institute of Neuroscience, Chinese Academy of Sciences.
Regulation of Neurite Initiation and Dendrite Morphogenesis by the Phospholipid PI(3,4)P2 (2017-1-22)
Using cultured rat hippocampal neurons and a combination of live imaging and pharmacological treatments, YU Xiang's lab showed that one or two large actin aggregates formed underneath the membrane of newborn neurons and served as the start sites of neurite initiation.
Top-down Cortical Feedback Selectively Gates Visual Information Flow from the Thalamus Back to the Visual Cortex (2017-1-21)
In a recent paper from Dr WANG Wei's group, published online in Cerebral Cortex on December 17th 2016, the researchers used focally specific causal manipulation to study a key feedback connection in the visual system (the corticothalamic loop).
Perceptual Asymmetry for Dark and Bright Afterimages is Paralleled by Neuronal Response Differences in Subcortical ON and OFF Channels (2017-1-16)
Researchers from Dr. WANG Wei’s lab at ION took advantage of the known differences between the perception of dark and bright stimuli to test whether such asymmetries also exist for bright and dark afterimages, and then probe the underlying neuronal mechanisms generating afterimage perception.
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