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Solving the Puzzle: How Neuronal Circuits in the Neocortex Make Causal Contributions to Decision-Making (2019-4-29)
A recent study published in Nature Neuroscience from Dr. XU Ninglong’s lab at the Institute of Neuroscience, Chinese Academy of Sciences, now provided new insights into the functional role of PPC in decision-making. In this study, ZHONG et al. obtained compelling evidence to show that PPC indeed plays an essential role in decision-making under critical conditions that were largely ignored in previous studies. The authors employed a novel behavioral technique in mice combined with precise manipulation and monitoring of neuronal activity in PPC, using optogenetics, chemogenetics and in vivo two-photon imaging.
A Novel Therapeutic Strategy for ALS (2019-4-8)
A study published online in Brain on April 1st has revealed a new cellular mechanism for amyotrophic lateral sclerosis (ALS), suggested a novel therapeutic strategy targeting the RNA degradation pathway, and identified an asthma drug as a potential medication for ALS. This work was mainly conducted by researchers from Dr. XU Jin’s lab at the Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences.
Neurotassel Can Read Brain Activity for Long Periods of Time (2019-4-1)
Researchers at the National Center of Nanoscience and Technology of China (NCNST) and the Institute of Neuroscience (ION), Chinese Academy of Sciences, have developed an ultrasmall and flexible Neurotassel that can record neuron firing in awake mice for long periods of time. The researchers described their findings in a research article published on Mar. 27 in Science Advances, 2019.
GOTI Makes Off-Target Nowhere to Hide (2019-2-28)
On March 1st, a paper entitled “Cytosine base editor generates substantial off-target single nucleotide variants in mouse embryos” was published on Science. The researchers developed a method named “GOTI” and applied to evaluate the genome-wide off-target effects induced by genome editing tools including CRISPR/Cas9 and base editors.
Going with the Flow: The Neural Mechanisms Underlying Illusions of Complex-Flow Motion (2019-2-18)
Researchers at the Institute of Neuroscience provide the first detailed analysis of the neuronal mechanisms underlying complex forms of illusory motion integration from MT to MSTd. Specifically, the same motion-specific neural groups in MSTd that normally encode physical flow motions also mediate illusory flow motions through a bottom-up cascade of integration of non-veridical local motion signals, yet reliable discrimination is temporally delayed for the illusion.
Gene-edited Disease Monkeys Cloned in China (2019-1-23)
The first cohort of five gene-edited monkey clones made from fibroblasts of a monkey with disease phenotypes were born recently at the Institute of Neuroscience (ION) of Chinese Academy of Sciences (CAS) in Shanghai. This major advance, reported on-line in two articles in the journal National Science Review on January 24.
New Study Reveals Molecular Basis of the Proton Sensor on the Human GluN1/GluN2A NMDA Receptors (2018-12-26)
New Study Reveals Molecular Basis of the Proton Sensor on the Human GluN1/GluN2A NMDA Receptors A recent study from Dr. ZHU Shujia’s Laboratory etc. published in Cell Reports resolved the first three-dimensional Cryo-EM structure of human GluN1/GluN2A NMDA (N-methyl-D-aspartic acid) receptors at near-atomic resolution. This work demonstrated the structural basis and molecular mechanism of proton inhibition on this key neuronal excitatory receptor.
Researchers Identified Brain Cells Gating the Itch-Scratching Cycle (2018-12-13)
A recent study published in Neuron demonstrated that tachykinin 1 (Tac1)-expressing neurons in the periaqueductal gray (PAG) facilitate the itch-scratching cycle via descending regulation. This work was performed by researchers in Dr. SUN Yan-Gang’s Lab at the Institute of Neuroscience, Chinese Academy of Sciences.
New Study Reveal Starvation Inhibition of Maternal Nest-Building Behavior (2018-11-21)
On November 20th, the "Journal of Neuroscience" published a research paper entitled "Agrp neurons project to the medial preoptic area and modulate maternal nest-building". This study was conducted by the team of XU Xiao-Hong in the Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences and the State Key Laboratory of Neuroscience. In this study, the team explored the mutual antagonism between hunger and maternal behaviors, as well as the neural basis for such behavioral interactions.
Establishment of Collaborative International Biomedical Research Center and First Symposium among Collège de France, Shanghai Jiaotong University School of Medicine, and Institute of Neuroscience, Chinese Academy of Sciences (2018-11-7)
To foster close interaction and encourage future collaboration, three top biomedical institutions of France and China established joint center for MOU and held the first trio-party symposium in Shanghai on October 31, 2018. Dr. Zhu Chen, vice chairman of Standing Committee of the National People's Congress of China, attended the ceremony and symposium.
Modulation of itch signal processing by dopaminergic neurons in the ventral tegmental area (2018-9-29)
A recent study published in Journal of Neuroscience demonstrated that dopaminergic neurons in the ventral tegmental area (VTA) play important roles in modulating itch signals. This work was performed by researchers in Dr. SUN Yan-gang’s Lab at the Institute of Neuroscience, Chinese Academy of Sciences.
PDGFRβ Cells Rapidly Relay Inflammatory Signal from the Circulatory System to Neurons via Chemokine CCL2 (2018-9-28)
A recent study published in Neuron demonstrated in vivo that PDGFRβ-expressing mural cells of the brain vasculature function as initial sensors of external insults, and secrete chemokine CCL2 to relay the signal to neurons in multiple brain regions, to increase excitatory synaptic transmission and total neuronal excitability.
Researchers Develop a New Tool for Identification of Small-Molecule Ion Channel Modulators (2018-9-27)
A recent study published in the Nature communications reported an in vivo high-throughput method for screening compounds that have therapeutic potential in treating channelopathies. This work was performed by Dr. CAI Shiqing’s lab.
New Insights into Decoding Mechanisms of Sensory Signals (2018-9-21)
A recent study published in Neuron provides new insights into how neuronal signals in the sensory cortices is decoded, or read out, by downstream areas for decision making. This work was performed by researchers in the laboratory of Spatial Perception at the Institute of Neuroscience, CAS.
Roles and Mechanisms of the Locus Coeruleus in Intravenous General Anesthesia of Zebrafish (2018-9-18)
On September 18, an article entitled “The Locus Coeruleus Modulates Intravenous General Anesthesia of Zebrafish via a Cooperative Mechanism” was published in Cell Reports. This work was performed by Prof. YU Tian’s team at Zunyi Medical College and Dr. DU Jiulin’s lab at the Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Science.
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