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Identification of MYORG as a new causative gene for primary familial brain calcification (2018-6-15)
A recent study published in Neuron demonstrated that mutation of MYORG gene is a new causative factor for primary familial brain calcification. This finding resulted from a joint work by Prof. CHEN Wan-Jin and Prof. WANG Ning’s team and Dr. XIONG Zhi-Qi’s lab.
The 8th Academic Review of ION PIs and the 9th International Advisory Board Meeting were held in Shanghai (2018-5-31)
From May 28th to 30th, the 8th Academic Review of ION PIs and the 9th International Advisory Board Meeting were held in Shanghai.
Efficient and Precise Gene Knock-in Using Tild-CRISPR in Mouse and Human Cells (2018-5-22)
A recent study published in Developmental Cell demonstrated that the efficient and precisely targeted integration can be achieved by Tild-CRISPR in mouse and human cells. This work was performed by researchers in Dr. YANG Hui’s Lab, in collaboration with the team of Dr. CHEN Zi-jiang .
Mechanism and Predictor of the Clinical Efficacy of Psychosurgery in Severe Obsessive-Compulsive Disorder (2018-4-24)
On April 21, an article named “Dissociable Frontostriatal Connectivity: Mechanism and Predictor of the Clinical Efficacy of Capsulotomy in Obsessive-Compulsive Disorder” online published in Biological Psychiatry.
Attention Guides Value Encoding in the Orbitofrontal Cortex (2018-4-11)
A recent study published in eLife by researchers in Dr. Yang Tianming’s lab showed that the neuronal activity in the orbitofrontal cortex (OFC) represents the value of the attended item. The findings indicated that the processing of value information in the brain may be a sequential process and attention plays a key role in guiding this process.
Targeted Blocking of Nuclear Import Kills Glioblastoma via Proteotoxic Stress (2018-4-10)
A recent study published in Oncogene demonstrated that glioblastoma (GBM) cells depleted of the nuclear import receptor KPNB1 exhibits proteotoxic stress and apoptosis. This work was performed by researchers in Dr. XIONG Zhi-Qi’s Lab.
Seeing the forest before the trees: researchers uncover novel brain mechanisms preserving vision with high resolution (2018-3-30)
In a recent study published in Neuron, Dr. WANG Wei’s lab at the Institute of Neuroscience of the Chinese Academy of Sciences studied how local high-resolution information may in fact be conserved from early to intermediate areas of the visual hierarchy in an animal model of vision that is closest to our own, the macaque monkey.
Meet Zhong Zhong and Hua Hua, the First Monkey Clones Produced by Method that Made Dolly (2018-1-25)
The first primate clones made by somatic cell nuclear transfer are two genetically-identical long-tailed macaques born recently at the Institute of Neuroscience. Researchers named the newborns Zhong Zhong and Hua Hua.
Researchers Find a Bi-Sexual Layout of the Brain for Sex-Typical Behaviors (2018-1-19)
In a recent study published in Nature Communications entitled “Medial preoptic area in mice is capable of mediating sexually dimorphic behaviors regardless of gender”, WEI and colleagues in Dr. XU Xiaohong’s lab showed unexpectedly that a well-known sexually dimorphic brain nucleus can drive both male-typical and female-typical behaviors.
In vivo simultaneous transcriptional activation ofmultiple genes in the brain using CRISPR–dCas9-activator transgenic mice (2018-1-16)
A recent study published in Nature Neuroscience demonstrated that the transcription of multiple genes in the brain can be simultaneously activated usingCRISPR–dCas9-activator transgenic mice. This work was completed by researchers in Dr. YANG Hui’s Lab.
Generation of Knock-In Cynomolgus Monkey Using CRISPR/Cas9-Mediated HMEJ-Based Strategy (2018-1-12)
A recent study published in Cell Research demonstrated that homology-mediated end joining (HMEJ)-based strategy can generate knock-in cynomolgus monkey using CRISPR/Cas9. This work was performed by researchers in Dr. YANG Hui’s Lab, in collaboration with the teams of Dr. SUN Qiang.
Whole-brain Atlas of the Cholinergic System and Mesoscopic Projectome of Basal Forebrain Cholinergic Neurons (2017-12-20)
A recent study published in PNAS provides a precise 3-D whole-brain atlas for the cholinergic system and the complete morphology of individual cholinergic neuron in the basal forebrain.
Targeted Chromosome Elimination by CRISPR/Cas9-Mediated Genome Editing (2017-11-25)
A recent study published in Genome Biology demonstrated that an entire Chromosomecould be eliminated by CRISPR/Cas9-mediated genome editing. This work was performed by researchers in Dr. YANG Hui’s Lab at the Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, and Dr. HU Jiazhi’sLab at the Peking University.
Researchers Uncover the Genetic Basis of Natural Variation in Aging Rate (2017-11-8)
A recent study published in Nature uncovered the genetic basis of natural variation in aging rate. This work was carried out by researchers from Dr. CAI Shiqing’s lab at the Institute of Neuroscience and State Key Laboratory of Neuroscience, CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences.
New Brake for Synaptic Vesicle Docking and Movement Controlling (2017-11-3)
A recent study carried out by Dr.Tan et al from Dr. XIONG Zhiqi’s laboratory, at the Institute of Neuroscience, Chinese Academy of Sciences, showed that PRRT2 is a presynaptic protein that interacts with components of SNARE complex and down-regulates its formation.
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