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New Mechanism of Auditory Categorization in the Cortical Neuronal Populations (2019-7-8)
A recent study published in Neuron demonstrates that neuronal ensembles in mouse auditory cortex exhibit dynamic changes to facilitate stimulus categorization when the animals are engaged in a perceptual categorization task. This work was performed by researchers in Dr. XU Ninglong’s Lab at the Center for Excellence in Brain Science and Intelligence Technology,CAS.
DNA Base Editing Induces Substantial Off-target RNA Mutations and Their Elimination by Mutagenesis (2019-6-10)
In a study published in Nature on June 10, researchers from Dr. YANG Hui’s Lab at the Institute of Neuroscience of the Chinese Academy of Sciences (CAS), and collaborators from the CAS-MPG Partner Institute for Computational Biology of CAS and Sichuan University demonstrated that DNA base editors generated tens of thousands of off-target RNA single nucleotide variants (SNVs) and these off-target SNVs could be eliminated by introducing point mutations to the deaminases.
Acute glaucoma impairs visual acuity towards central visual field in non-human primates (2019-6-9)
A recent study published in EBioMedicine provides new insights into the impact of acute elevations of intraocular pressure (IOP) that occur during the disease Glaucoma. This work, in collaboration with Dr. Xinghuai Sun’s group at the Eye and ENT Hospital of Fudan University, was performed at Dr. Wei Wang’s Lab at the Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, CAS.
Modulatory Roles of Glial Cells in Spontaneous Retinal Waves (2019-6-4)
The researchers from Dr. DU Jiulin’s lab at the Institute of Neuroscience, State Key Laboratory of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, found that Müller glial cells (MGCs) participate in and modulate retinal waves via AMPA receptors and glutamate transporters on their own processes respectively, by using in vivo calcium imaging and electrophysiological recording in larval zebrafish.
Identifying a New Target for Therapeutic Intervention to UBE3A-Related Neurodevelopmental Disorders (2019-6-3)
A recent study published in PNAS implicates a critical role of UBE3A-PTPA-PP2A signaling in the pathogenesis of UBE3A-related disorders and suggests a target for therapeutic intervention to Angelman syndrome and autism. This work was performed by researchers in Dr. XIONG Zhiqi’s Lab at the Center for Excellence in Brain Science and Intelligence Technology, Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Science and Prof. LIAO Lujian’s Lab at East China Normal University.
Human Cleaving Embryos Enable Robust Homozygotic Nucleotide Substitutions by Base Editors (2019-5-24)
A recent study published in Genome Biology demonstrated that human cleaving embryos enable robust homozygotic nucleotide substitutions by base editors. This study was performed by researchers in Dr. YANG Hui’s Lab, Dr. CHEN Zijiang’s team and Dr. Shoukhrat Mitalipov’s lab. This work has successfully developed a robust method to remarkably improve base editing efficiency in human cleaving embryos.
Solving the Puzzle: How Neuronal Circuits in the Neocortex Make Causal Contributions to Decision-Making (2019-4-29)
A recent study published in Nature Neuroscience from Dr. XU Ninglong’s lab at the Institute of Neuroscience, Chinese Academy of Sciences, now provided new insights into the functional role of PPC in decision-making. In this study, ZHONG et al. obtained compelling evidence to show that PPC indeed plays an essential role in decision-making under critical conditions that were largely ignored in previous studies. The authors employed a novel behavioral technique in mice combined with precise manipulation and monitoring of neuronal activity in PPC, using optogenetics, chemogenetics and in vivo two-photon imaging.
A Novel Therapeutic Strategy for ALS (2019-4-8)
A study published online in Brain on April 1st has revealed a new cellular mechanism for amyotrophic lateral sclerosis (ALS), suggested a novel therapeutic strategy targeting the RNA degradation pathway, and identified an asthma drug as a potential medication for ALS. This work was mainly conducted by researchers from Dr. XU Jin’s lab at the Institute of Neuroscience, State Key Laboratory of Neuroscience, Chinese Academy of Sciences.
Neurotassel Can Read Brain Activity for Long Periods of Time (2019-4-1)
Researchers at the National Center of Nanoscience and Technology of China (NCNST) and the Institute of Neuroscience (ION), Chinese Academy of Sciences, have developed an ultrasmall and flexible Neurotassel that can record neuron firing in awake mice for long periods of time. The researchers described their findings in a research article published on Mar. 27 in Science Advances, 2019.
GOTI Makes Off-Target Nowhere to Hide (2019-2-28)
On March 1st, a paper entitled “Cytosine base editor generates substantial off-target single nucleotide variants in mouse embryos” was published on Science. The researchers developed a method named “GOTI” and applied to evaluate the genome-wide off-target effects induced by genome editing tools including CRISPR/Cas9 and base editors.
Going with the Flow: The Neural Mechanisms Underlying Illusions of Complex-Flow Motion (2019-2-18)
Researchers at the Institute of Neuroscience provide the first detailed analysis of the neuronal mechanisms underlying complex forms of illusory motion integration from MT to MSTd. Specifically, the same motion-specific neural groups in MSTd that normally encode physical flow motions also mediate illusory flow motions through a bottom-up cascade of integration of non-veridical local motion signals, yet reliable discrimination is temporally delayed for the illusion.
Gene-edited Disease Monkeys Cloned in China (2019-1-23)
The first cohort of five gene-edited monkey clones made from fibroblasts of a monkey with disease phenotypes were born recently at the Institute of Neuroscience (ION) of Chinese Academy of Sciences (CAS) in Shanghai. This major advance, reported on-line in two articles in the journal National Science Review on January 24.
New Study Reveals Molecular Basis of the Proton Sensor on the Human GluN1/GluN2A NMDA Receptors (2018-12-26)
New Study Reveals Molecular Basis of the Proton Sensor on the Human GluN1/GluN2A NMDA Receptors A recent study from Dr. ZHU Shujia’s Laboratory etc. published in Cell Reports resolved the first three-dimensional Cryo-EM structure of human GluN1/GluN2A NMDA (N-methyl-D-aspartic acid) receptors at near-atomic resolution. This work demonstrated the structural basis and molecular mechanism of proton inhibition on this key neuronal excitatory receptor.
Researchers Identified Brain Cells Gating the Itch-Scratching Cycle (2018-12-13)
A recent study published in Neuron demonstrated that tachykinin 1 (Tac1)-expressing neurons in the periaqueductal gray (PAG) facilitate the itch-scratching cycle via descending regulation. This work was performed by researchers in Dr. SUN Yan-Gang’s Lab at the Institute of Neuroscience, Chinese Academy of Sciences.
New Study Reveal Starvation Inhibition of Maternal Nest-Building Behavior (2018-11-21)
On November 20th, the "Journal of Neuroscience" published a research paper entitled "Agrp neurons project to the medial preoptic area and modulate maternal nest-building". This study was conducted by the team of XU Xiao-Hong in the Institute of Neuroscience, Center for Excellence in Brain Science and Intelligence Technology of the Chinese Academy of Sciences and the State Key Laboratory of Neuroscience. In this study, the team explored the mutual antagonism between hunger and maternal behaviors, as well as the neural basis for such behavioral interactions.
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