中国科学院神经科学研究所
    神经可塑性分子基础研究组
代表性论文
1.Liu XY#, Liu LX#, Ji Y#, Li CY#, Wei T, Yang XR, Zhang YF, Cai XY, Gao YB, Xu WH, Rao SX, Jin DY, Lou WH*, Qiu Z*, Wang X* (2019) Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer. EBioMedicine. DOI:10.1016/j.ebiom.2019.02.010
2.Cai Y#, Cheng TL#, Yao Y#, Li X, Ma Y, Bao J, Li L, Zhao H, Zhang M*, Qiu Z*, Xue T*. (2019) In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Science Advance. In press.
3.Qiu ZL* (2018) Deciphering MECP2 - associated disorders: disrupted circuits and the hope for repair. Curr. Opin. Neurobiol. 48:30-36. (Invited review)
4.Li X#, Yu B#, Sun Q, Zhang Y, Ren M, Zhang X, Li A, Yuan J, Madisen L, Luo Q, Zeng H, Gong H*, Qiu Z* (2018) Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons. Proc Natl Acad Sci USA. 115(2):415-420
5.Yang K, Yu B, Cheng C, Cheng TL, Yuan B, Li K, Xiao JH, Qiu ZL*, Zhou, Y.*(2017) Mir505-3p regulates axonal development via inhibiting the autophagy pathway by targeting Atg12. Autophagy. doi: 10.1080/15548627.2017.1353841.
6.Wen Z, Cheng TL, Yin DZ, Sun SB, Wang Z, Yu SY, Zhang Y*, Qiu Z*, Du YS*. (2017) Identification of the Genetic Cause for Childhood Disintegrative Disorder by Whole-Exome Sequencing. Neurosci Bull. 33(2):251-254
7.Wen Z , Cheng TL , Li GZ, Sun SB, Yu SY, Zhang Y*, Du YS*, Qiu Z* (2017) Identification of Autism-Related MECP2 Mutations by Whole Exome Sequencing and Functional Validation. Molecular Autism. 8:43. doi: 10.1186/s13229-017-0157-5
8.Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z*, Ye D*, Guan KL*. L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration. Mol Cell Biol. (2017) pii: MCB.00492-16. doi: 10.1128/MCB.00492-16.
9.Dang T, Duan W,Yu B, Tong DL,Cheng C, Zhang YF, Wu W, YeK, Zhang WX, WuM, WuBB, AnY, Qiu Z*,BL Wu*, (2017) Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development. Molecular Psychiatry doi:10.1038/mp.2016.253
10.Cheng TL.*, Chen J., Wan H., Tang B., Tian W., Liao L.*, Qiu Z.* (2017) Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain. Scientific Reports 7:42790. doi: 10.1038/srep42790
11.Chen Z, Li X, Zhou J, Yuan B, Yu B, Tong D, Cheng C, Shao Y, Xia S, Zhang R, Lyu J, Yu X, Dong C, Zhou WH, Qiu Z.*(2017)Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome.Scientific Reports.7:41701. doi: 10.1038/srep41701.
12.Yuan B, Cheng TL, Yang K, Zhang X, Qiu Z*. (2017) Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors. Journal of Genetics and Genomics. pii: S1673-8527(16)30153-9. doi: 10.1016/j.jgg.2016.10.004.
13.Liu, Z., Li, X., Zhang, J., Cai, Y., Cheng, T., Cheng, C., Wang, Y., Zhang, C., Nie, Y., Chen, Z., Bian, W., Zhang, L., Xiao, J., Lu, B., Zhang, Y., Zhang, X., Sang, X., Wu, J., Xu, X., Xiong, Z., Zhang, F., Yu, X., Gong, N., Zhou, W., Sun, Q.* & Qiu, Z.*(2016)Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature 530:98-102
14.Li H, Zhao P, Xu Q, Shan S, Hu C, Qiu Z*, Xu X* (2016) The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1. Scientific Reports. 6:29878. doi: 10.1038/srep29878.
15.Jennings CG, Landman R, Zhou Y, Sharma J, Hyman J, Movshon JA, Qiu Z, Roberts AC, Roe AW, Wang X, Zhou H, Wang L, Zhang F, Desimone R, Feng G. (2016) Opportunities and challenges in modeling human brain disorders in transgenic primates.Nature Neuroscience 19(9):1123-30
16.Zhang R, Huang M, Cao Z, Qi J, Qiu Z*, Chiang LY* (2015) MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway. Mol Pain. 11:19. doi: 10.1186/s12990-015-0015-4.
17.Xin, Y., Yuan, B., Yu, B., Wang, Y., Wu, J., Zhou, W.*, Qiu, Z.* (2015) Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress. Scientific Reports 5:7645. doi: 10.1038/srep07645.
18.Liu, Z., Zhou, X., Zhu, Y., Chen, Z., Yu, B., Wang, Y., Zhang, C., Nie, Y., Sang, X., Cai, Y.,  Zhang, Y., Zhang, C., Zhou, W., Sun, Q.*, and Qiu, Z.* (2014) Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci. Bull. 30: 381-386.
19.Cheng, T., Wang, Z., Liao, Q., Zhu, Y., Zhou, W., Xu, W., Qiu, Z.* (2014) MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Dev. Cell  28:547-560.
20.Zhang, Y., Mao, R., Chen, Z., Tian, M., Tong, D., Gao, Z., Huang, M., Li, X., Xu, X., Zhou, W., Li, C., Wang, J., Xu, L.*, Qiu, Z.* (2014) Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders. Mol. Brain 7:11.
21.Cheng, J., Huang, M., Zhu, Y., Xin, Y., Zhao, Y., Huang, J., Yu, J., Zhou, W.*, and Qiu, Z.* (2013) SUMOylation of MeCP2 is essential for transcriptional rep ression and hippocampal synapse development. J. Neurochem. 128:798-806.
22.Liu, X., Somel, M., Tang, L., Yan, Z., Jiang, X., Guo,S., Yuan,Y., Oleksiak, A., Zhang, Y., Li, N.,  Hu, Y., Chen, W., Qiu, Z.*, Pääbo, S.*, Khaitovich, P.* (2012) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. 22:611-622
23.Qiu, Z., Sylwestrak, E., Lieberman, D., Zhang, Y., Liu, X., Ghosh A.* (2012) The Rett syndrome protein MeCP2 regulates synaptic scaling. J. Neurosci. 32:989-94.
24. Qiu, Z.*, and Cheng, J. (2010) The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond. Neurosignals 18: 72-81. (Invited review)
25. Qiu, Z., and Ghosh, A.* (2008). A Calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 60: 775-787. (Highlighted in Molecular Biology Select of Leading Edge section on Cell at Jan. 29. 2009)
26. Qiu, Z., and Ghosh, A.* (2008). A brief history of neuronal gene regulation: regulatory mechanisms and cellular consequences. Neuron 60: 449-455. (Invited review)
27. Kashani, A. H., Qiu, Z., Jurata, L., Lee, S. K., Pfaff, S., Goebbels, S., Nave, K. A., and Ghosh, A.* (2006). Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J. Neurosci. 26: 8398-8408.
28. Qiu, Z., Wei, Y., Chen, N., Jiang, M., Wu, J.*, and Liao, K.* (2001). DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J. Biol. Chem. 276: 11988-11995.
发表论文
1.Liu XY#, Liu LX#, Ji Y#, Li CY#, Wei T, Yang XR, Zhang YF, Cai XY, Gao YB, Xu WH, Rao SX, Jin DY, Lou WH*, Qiu Z*, Wang X* (2019) Enrichment of short mutant cell-free DNA fragments enhanced detection of pancreatic cancer. EBioMedicine. DOI:10.1016/j.ebiom.2019.02.010
2.Cai Y#, Cheng TL#, Yao Y#, Li X, Ma Y, Bao J, Li L, Zhao H, Zhang M*, Qiu Z*, Xue T*. (2019) In vivo genome editing rescues photoreceptor degeneration via a Cas9/RecA-mediated homology-directed repair pathway. Science Advance. In press.
3.Cheng, T.*, and Qiu, Z.* (2018) Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion. Protein Cell 9: 820-825.
4.Zhou, N., Qin, S., Liu, Y., Tang, L., Zhao, W., Pan, C., Qiu, Z.*, Wang, X.*, and Shu, X.* (2018) Whole-exome sequencing identifies rare compound heterozygous mutations in the MYBPC3 gene associated with severe familial hypertrophic cardiomyopathy. Eur. J. Med. Genet. 61: 434-441.
5.Qiu ZL* (2018) Deciphering MECP2 - associated disorders: disrupted circuits and the hope for repair. Curr. Opin. Neurobiol. 48:30-36. (Invited review)
6.Li X#, Yu B#, Sun Q, Zhang Y, Ren M, Zhang X, Li A, Yuan J, Madisen L, Luo Q, Zeng H, Gong H*, Qiu Z* (2018) Generation of a whole-brain atlas for the cholinergic system and mesoscopic projectome analysis of basal forebrain cholinergic neurons. Proc Natl Acad Sci USA. 115(2):415-420
7.Cheng TL*, and Qiu ZL* (2017) Long non-coding RNA tagging and expression manipulation via CRISPR/Cas9-mediated targeted insertion. Protein Cell in press.
8.Tian YL, Yang CJ, Shang SJ, Cai YJ, Deng XF, Zhang J, Shao F, Zhu DS, Liu YB, Chen GQ, Liang J*, Sun Q*, Qiu ZL*, and Zhang C* (2017) Loss of FMRP impaired hippocampal long-term plasticity and spatial learning in rats. Front. Mol. Neurosci. 10: 269.
9.Yang K, Yu B, Cheng C, Cheng TL, Yuan B, Li K, Xiao JH, Qiu ZL*, Zhou, Y.*(2017) Mir505-3p regulates axonal development via inhibiting the autophagy pathway by targeting Atg12. Autophagy. doi: 10.1080/15548627.2017.1353841.
10.Zhang D, Yu B, Liu J, Jiang W, Xie T, Zhang R, Tong D, Qiu Z, Yao H*. (2017) Altered visual cortical processing in a mouse model of MECP2 duplication syndrome. Sci. Rep. 7(1):6468.
11.Wen Z, Cheng TL, Yin DZ, Sun SB, Wang Z, Yu SY, Zhang Y*, Qiu Z*, Du YS*. (2017) Identification of the Genetic Cause for Childhood Disintegrative Disorder by Whole-Exome Sequencing. Neurosci Bull. 33(2):251-254.
12.Wang M, Li H, Takumi T, Qiu Z, Xu X, Yu X, Bian WJ*. (2017) Distinct Defects in Spine Formation or Pruning in Two Gene Duplication Mouse Models of Autism. Neurosci Bull. 33(2):143-152.
13.Wen Z , Cheng TL , Li GZ, Sun SB, Yu SY,  Zhang Y*, Du YS*, Qiu Z* (2017) Identification of Autism-Related MECP2 Mutations by Whole Exome Sequencing and Functional Validation. Molecular Autism. 8:43. doi: 10.1186/s13229-017-0157-5
14.Ma S, Sun R, Jiang B, Gao J, Deng W, Liu P, He R, Cui J, Ji M, Yi W, Yang P, Wu X, Xiong Y, Qiu Z*, Ye D*, Guan KL*. L2hgdh deficiency accumulates L-2-hydroxyglutarate with progressive leukoencephalopathy and neurodegeneration. Mol Cell Biol. (2017) pii: MCB.00492-16. doi: 10.1128/MCB.00492-16.
15.Dang T, Duan W,Yu B, Tong DL,Cheng C, Zhang YF, Wu W, YeK, Zhang WX, WuM, WuBB, AnY, Qiu Z*,BL Wu*, (2017) Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical development. Molecular Psychiatry doi:10.1038/mp.2016.253
16.Cheng TL.*, Chen J., Wan H., Tang B., Tian W., Liao L.*, Qiu Z.* (2017) Regulation of mRNA splicing by MeCP2 via epigenetic modifications in the brain. Scientific Reports 7:42790. doi: 10.1038/srep42790
17.Chen Z, Li X, Zhou J, Yuan B, Yu B, Tong D, Cheng C, Shao Y, Xia S, Zhang R, Lyu J, Yu X, Dong C, Zhou WH, Qiu Z.* (2017)Accumulated quiescent neural stem cells in adult hippocampus of the mouse model for the MECP2 duplication syndrome.Scientific Reports.7:41701. doi: 10.1038/srep41701
18.Yuan B, Cheng TL, Yang K, Zhang X, Qiu Z*. (2017) Autism-related protein MeCP2 regulates FGF13 expression and emotional behaviors. Journal of Genetics and Genomics. pii: S1673-8527(16)30153-9. doi: 10.1016/j.jgg.2016.10.004.
19.Liu, Z., Li, X., Zhang, J., Cai, Y., Cheng, T., Cheng, C., Wang, Y., Zhang, C., Nie, Y., Chen, Z., Bian, W., Zhang, L., Xiao, J., Lu, B., Zhang, Y., Zhang, X., Sang, X., Wu, J., Xu, X., Xiong, Z., Zhang, F., Yu, X., Gong, N., Zhou, W., Sun, Q.* & Qiu, Z.*(2016)Autism-like behaviours and germline transmission in transgenic monkeys overexpressing MeCP2. Nature 530:98-102
20.Yao XH, Wang M, He XN, He F, Zhang SQ, Lu W, Qiu Z, Yu YC* (2016) Electrical coupling regulates layer 1 interneuron microcircuit formation in the neocortex. Nat Commun. 7:12229.
21.Li H, Zhao P, Xu Q, Shan S, Hu C, Qiu Z*, Xu X* (2016)  The autism-related gene SNRPN regulates cortical and spine development via controlling nuclear receptor Nr4a1. Scientific Reports. 6:29878. doi: 10.1038/srep29878.
22.Liu X, Han D, Somel M, Jiang X, Hu H, Guijarro P, Zhang N, Mitchell A, Halene T, Ely JJ, Sherwood CC, Hof PR, Qiu Z, Pääbo S*, Akbarian S*, Khaitovich P*. (2016) Disruption of an Evolutionarily Novel Synaptic Expression Pattern in Autism. PLoS Biolology. 14(9):e1002558. doi:10.1371/journal.pbio.1002558.
23.Zhang Y, Chen M, Qiu Z, Hu K, McGee W, Chen X, Liu J, Zhu L*, Wu JY*. (2016) Protein& Cell. 7(7):489-500. doi: 10.1007/s13238-016-0272-7.
24.Jennings CG, Landman R, Zhou Y, Sharma J, Hyman J, Movshon JA, Qiu Z, Roberts AC, Roe AW, Wang X, Zhou H, Wang L, Zhang F, Desimone R, Feng G. (2016) Opportunities and challenges in modeling human brain disorders in transgenic primates.Nature Neuroscience 19(9):1123-30
25.Lyu, J., Yuan, B., Cheng, T., Qiu, Z., Zhou, W.* (2016)Reciprocal regulation of autism-related genes MeCP2 and PTEN via microRNAs. Scientific Reports 6:20392. DOI: 10.1038/srep20392
26.Chen, L., Yin, D., Wang, T., Guo, W., Dong, H., Xu, Q., Luo, Y., Cherasse, Y., Lazarus, M.,  Qiu, Z., Lu, J., Qu, W.,* Huang, Z.*(2016)Basal Forebrain Cholinergic Neurons Primarily Contribute to Inhibition of Electroencephalogram Delta Activity, Rather than Inducing Behavioral Wakefulness in Mice. Neuropsychopharmacology  DOI:10.1038/npp13
27.Liu, Z., Nie, Y., Zhang, C., Cai, Y., Wang, Y., Lu, H., Li, Y., Cheng, C.,  Qiu, Z., Sun, Q.*(2016)Generation of macaques with sperm derived from juvenile monkey testicular xenografts. Cell Research 26(1):139-14.
28.Fu, Y., Huang, C., Xu, X., Gu, H., Ye, Y., Jiang, C.,  Qiu, Z., Xie, X.* (2015)Direct reprogramming of mouse fibroblasts into cardiomyocytes with chemical cocktails. Cell Research 25(9):1013-1024.
29.Bian, W., Miao, W., He, S.,  Qiu, Z., Yu, X.*(2015)Coordinated Spine Pruning and Maturation Mediated by Inter-Spine Competition for Cadherin/Catenin Complexes. Cell 162(4):808-822.
30.Jiang, W., Hua, R., Wei, M., Li, C., Qiu, Z., Yang, X.*, Zhang, C.* (2015)An optimized method for high-titer lentivirus preparations without ultracentrifugation.  Scientific  Reports 5, 13875.
31.Lyu, J., Yu, X., He, L., Cheng, T., Zhou, J., Cheng, C., Chen, Z., Cheng, G.,  Qiu, Z., Zhou, W.*(2015)The protein phosphatase activity of PTEN is essential for regulating neural stem cell differentiation.  Molecular Brain 8, 26.
32.Zhou, J., Cheng, C.,  Qiu, Z., Zhou, W., Cheng, G.* (2015)Decreased connexin 43 in astrocytes inhibits the neuroinflammatory reaction in an acute mouse model of neonatal sepsis. Neuroscience Bulletin 31(6):763-768.
33.Ma, S., Chen, L., Lin, Y., Yan, H., Lv, J., Xiong, M., Li, J., Cheng, G., Yang, Y.,  Qiu, Z., Zhou, W.* (2015)Periostin Promotes Neural Stem Cell Proliferation and Differentiation following Hypoxic-Ischemic Injury. PLos One 10(4), p e0123585.
34.Hou, B., Zhang, D., Zhao, S., Wei, M., Yang, Z., Wang, S., Wang, J., Zhang, X., Liu, B., Fan, L., Li, Y.,  Qiu, Z., Zhang, C., Jiang, T.* (2015)Scalable and DiI-compatible optical clearance of the mammalian brain. Frontiers in Neuroanatomy 9, p 19.
35.Zhang R, Huang M, Cao Z, Qi J, Qiu Z*, Chiang LY* (2015)  MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway. Mol Pain. 11:19. doi: 10.1186/s12990-015-0015-4.
36.Chen, L., Ma, S., Zhang, P., Fan, Z., Xiong, M., Cheng, G., Yang, Y.,  Qiu, Z., Zhou, W.,* Li, J.* (2015)Neuroprotective effects of oligodendrocyte progenitor cell transplantation in premature rat brain following hypoxic-ischemic injury.  PLos One 10(3), p e0115997.
37.Zhang, R., Huang, M., Cao, Z., Qi, J., Qiu, Z.*, and Chiang, L.* (2015) MeCP2 plays an analgesic role in pain transmission through regulating CREB / miR-132 pathway. Mol. Pain 11: 19.
38.Xin, Y., Yuan, B., Yu, B., Wang, Y., Wu, J., Zhou, W.*, Qiu, Z.* (2015) Tet1-mediated DNA demethylation regulates neuronal cell death induced by oxidative stress. Scientific Reports 5:7645. doi: 10.1038/srep07645.
39.He, L., Liu, N., Cheng, T., Chen, X., Li, Y., Shu, Y.,  Qiu, Z.,  Zhang, X.* (2014)Conditional deletion of Mecp2 in parvalbumin-expressing GABAergic cells results in the absence of critical period plasticity  Nature Communications, 5(5036):1-15.
40.Yang, L., Shen, C., Mei, M., Zhan, G., Zhao, Y., Wang, H., Huang, G.,  Qiu, Z., Lu, W., Zhou, W.* (2014)De novo GLI3 mutation in esophageal atresia: reproducing the phenotypic spectrum of Gli3 defects in murine models. Biochimica et Biophysica Acta: Molecular Basis of Disease 1842(9):1755-1761.
41.Cheng, T.*, and Qiu, Z. (2014) MeCP2: multifaceted roles in gene regulation and neural development. Neurosci. Bull. 30: 601-609. (Review)
42.Liu, Z., Zhou, X., Zhu, Y., Chen, Z., Yu, B., Wang, Y., Zhang, C., Nie, Y., Sang, X., Cai, Y.,  Zhang, Y., Zhang, C., Zhou, W., Sun, Q.*, and Qiu, Z.* (2014) Generation of a monkey with MECP2 mutations by TALEN-based gene targeting. Neurosci. Bull. 30: 381-386.
43.Cheng, T., Wang, Z., Liao, Q., Zhu, Y., Zhou, W., Xu, W., Qiu, Z.* (2014) MeCP2 suppresses nuclear microRNA processing and dendritic growth by regulating the DGCR8/Drosha complex. Dev. Cell  28:547-560.
44.Zhang, Y., Mao, R., Chen, Z., Tian, M., Tong, D., Gao, Z., Huang, M., Li, X., Xu, X., Zhou, W., Li, C., Wang, J., Xu, L.*, Qiu, Z.* (2014) Deep-brain magnetic stimulation promotes adult hippocampal neurogenesis and alleviates stress-related behaviors in mouse models for neuropsychiatric disorders. Mol. Brain 7:11.
45.Cheng, J., Huang, M., Zhu, Y., Xin, Y., Zhao, Y., Huang, J., Yu, J., Zhou, W.*, and Qiu, Z.*(2013) SUMOylation of MeCP2 is essential for transcriptional rep ression and hippocampal synapse development. J. Neurochem. 128:798-806.
46.Lv, J., Xin, Y., Zhou, W., and Qiu, Z.* (2013) The epigenetic switches for neural development and psychiatric disorders. J. Genet. Genomics 40: 339-346.
47.Xu, X.*, Xu, Q., Zhang, Y., Zhang, X., Cheng, T., Wu, B., Ding, Y., Lu, P., Zheng, J., Zhang, M., Qiu, Z., and Yu, X.*(2012) A case report of Chinese brothers with inherited MECP2-containing duplication: autism and intellectual disability, but not seizures or respiratory infections. BMC Med. Genet. 13: 75.
48.Gong, X., Jiang, Y., Zhang, X., An, Y., Zhang, J., Wu, Y., Wang, J., Sun, Y., Liu, Y., Gao, X., Shen, Y., Wu, X., Qiu, Z., Jin, L., Wu, B.*, Wang, H.* (2012) High Proportion of 22q13 Deletions and SHANK3 Mutations in Chinese Patients with Intellectual Disability. PLoS One. 7:e34739.
49.Wilke, S., Hall, B., Antonios, J., Denardo, L., Otto, S., Yuan, B., Chen, F., Robbins, E., Tiglio, K., Williams, M., Qiu, Z., Biederer, T., Ghosh, A.* (2012) NeuroD2 regulates the development of hippocampal mossy fiber synapses.Neural Dev. 27:7-9.
50.Liu, X., Somel, M., Tang, L., Yan, Z., Jiang, X., Guo,S., Yuan,Y., Oleksiak, A., Zhang, Y., Li, N.,  Hu, Y., Chen, W., Qiu, Z.*, Pääbo, S.*, Khaitovich, P.* (2012) Extension of cortical synaptic development distinguishes humans from chimpanzees and macaques. Genome Res. 22:611-622
51.Qiu, Z., Sylwestrak, E., Lieberman, D., Zhang, Y., Liu, X., Ghosh A.* (2012) The Rett syndrome protein MeCP2 regulates synaptic scaling. J. Neurosci. 32:989-94.
52. Qiu, Z.*, and Cheng, J. (2010) The Role of Calcium-Dependent Gene Expression in Autism Spectrum Disorders: Lessons from MeCP2, Ube3a and Beyond. Neurosignals 18: 72-81. (Invited review)
53. Qiu, Z.* (2009) Histone modifier, the gatekeeper of good memory. Cell Res. 8: 920-921 (Research Highlight)
54. Qiu, Z., and Ghosh, A.* (2008). A Calcium-dependent switch in a CREST-BRG1 complex regulates activity-dependent gene expression. Neuron 60: 775-787. (Highlighted in Molecular Biology Select of Leading Edge section on Cell at Jan. 29. 2009)
55. Qiu, Z., and Ghosh, A.* (2008). A brief history of neuronal gene regulation: regulatory mechanisms and cellular consequences. Neuron 60: 449-455. (Invited review)
56. Yuan, S., Qiu, Z., and Ghosh, A.* (2008). Tox3: a CREB- and CBP-interacted protein that regulates calcium-dependent transcription in neurons. Proc. Natl. Acad. Sci. USA. 106: 2909-2914.
57. Wu, J. I., Lessard, J., Olave, I. A., Qiu, Z., Ghosh, A., Graef, I. A., and Crabtree, G. R.* (2007). Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron 56: 94-108.
58. Kashani, A. H., Qiu, Z., Jurata, L., Lee, S. K., Pfaff, S., Goebbels, S., Nave, K. A., and Ghosh, A.* (2006). Calcium activation of the LMO4 transcription complex and its role in the patterning of thalamocortical connections. J. Neurosci. 26: 8398-8408.
59. Qiu, Z., Wei, Y., Chen, N., Jiang, M., Wu, J.*, and Liao, K.* (2001). DNA synthesis and mitotic clonal expansion is not a required step for 3T3-L1 preadipocyte differentiation into adipocytes. J. Biol. Chem. 276: 11988-11995.
60. Qiu, Z, Guo, X. M. and Liao, K.* (2001). Analysis of the Relationship between Globally Regulated Genes and Their Chromosomal Genetic Map Loci during Adipogenesis. Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 33: 137-141.
61. Jin, S., Zhai, B., Qiu, Z., Wu, J., Lane, M. D., and Liao, K.* (2000). c-Crk, a substrate of the insulin-like growth factor-1 receptor tyrosine kinase, functions as an early signal mediator in the adipocyte differentiation process. J. Biol. Chem. 275: 34344-34352.
62. Tang, W. H, Qiu Z, Wang, Z, Zhang, J and Hong, M. M.* (1999). ACTA PHYTOPHYSIOLOGICA SINICA 25: 401-407.
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